Ezetimibe/simvastatin / ZETIA - FDA
Dec 14, 2015. Simvastatin and Ezetimibe in Aortic Stenosis SEAS Study.15. As part of the ezetimibe development program, three outcomes trials. Mar 9, 2016. Two previous outcomes trials, Simvastatin and Ezetimibe in Aortic Stenosis SEAS and Study of Heart and Renal Protection SHARP, studied. Ezetimibe is a drug that lowers plasma cholesterol levels. It acts by decreasing cholesterol. The trial results showing that ezetimibe treatment lowered the risk of experiencing a vascular event by 2%. Ezetimibe is indicated in the United States.
The ENHANCE Trial Analysis and Clinical Significance -
The ENHANCE trial is a randomized study aimed at studying the effect of ezetimibe on top of simvastatin versus simvastatin on carotid intima–media thickness in. Jun 3, 2015. When added to statin therapy, ezetimibe resulted in incremental lowering of. Figure 2 Plot of the IMPROVE-IT Trial Data and Statin Trials for.